GENEGUT brings together 9 partners from 8 European countries covering the lifecycle from bench to bedside.
Through a patient-centred approach and grown out of the recent Cost Action UNGAP (CA16205), GENEGUT brings together a patient association with renowned researchers, expert clinical scientists, SMEs and large pharma companies with expertise and patented technologies in global proteomics, nanotechnologies, cyclodextrin synthesis, multicellular models, drug delivery systems and production as well as innovation management, stakeholder involvement and science communication.
GENEGUT benefits from the special partnership between the University College Cork’s School of Pharmacy, represented by GENEGUT project coordinator Prof. Caitriona O’Driscoll, and the APC Microbiome Ireland SF1 Research Centre under principal investigator and Consultant Gastroenterologist Prof. Subrata Ghosh. Both research groups share a long history of fruitful collaboration, and a track record of translational research in the field of drug delivery and the treatment of inflammatory bowel disease. This partnership unites pre-clinical and clinical skills and will enable the UCC team to join forces for the development of an RNA-based therapy for ileal CD.
University College Cork (UCC)
School of Pharmacy
APC Microbiome
- Project coordination and management
- Synthesis, formulation and characterisation of therapeutic RNA-based nanoparticles
- Cellular specificity and mechanism
- Proof of efficiacy under diseased conditions
- Dr. Ken Nally
Bangor University (BU)
School of Medical Health Sciences
- Early Health Technology Assessment and Regulatory Preparedness
Institute for Research and Innovation in Health (i3S)
- Proof of efficiacy under diseased conditions
Efficiacy of targets on optimised 3D multicellular model of ileal CD
Uppsala University (UU)
- Cellular specificity and mechanism
Establish relevant healthy and diseased intestinal cell models
Kinetics and mechanisms of RNA nanoparticle uptake
Intracellular localization and endosomal escape
CarboHyde
- Synthesis, formulation and characterisation of therapeutic RNA-based nanoparticles
Chemistry of the biomaterials
Formulation and characterisation of NPs containing RNA
Janssen Pharmaceutica NV
Discovery, Product Development & Supply
Establishing simulated patient model of CD through in silico PBBM
Lonza Capsules & Health Ingredients - Capsugel SAS
- Formulation development for regional specificity
Drug delivery system targeted at ileocaecal junction
In vitro characterisation – stability and site-specific release
European Federation of Crohn's and Ulcerative Colitis Associations
- Communication, dissemination and exploitation of results
Disseminate scientific and technological results
accelopment Schweiz AG
- Project management and administration
- Communication and dissemination of results
- Innovation management and exploitation support
UK participants in Horizon Europe Project GENEGUT are supported by UKRI grant number 10042451 (Bangor University).