Welcome to another edition of our “GENEGUT: Behind the Scenes” series — where we spotlight the passionate teams driving innovation across the GENEGUT project. Today, we introduce Capsugel France SAS (Lonza Capsules and Health Ingredients), based in France.
Who They Are
Lonza Capsules and Health Ingredients is a global leader with 100+ years of expertise in capsule design, manufacturing, and encapsulation technology. Backed by advanced technology, world-class manufacturing, and scientific excellence, we collaborate throughout the development lifecycle to create customised solutions that deliver groundbreaking health products to market.
What They Do in GENEGUT
In the GENEGUT project, Lonza CHI is developing a tailored capsule-based technology to safely deliver RNA-based nanoparticles to the ileum. Our key tasks include designing a bilayer capsule with specialized polymers for targeted release and evaluating its in vitro performance to ensure effective delivery.
Why GENEGUT Matters
“We are excited to collaborate with leading scientists across Europe to develop an innovative capsule-based technology that could transform the quality of life for Crohn’s disease patients. This partnership drives scientific innovation, bringing us closer to a breakthrough in targeted drug delivery.”
The Future Impact of GENEGUT
“We hope GENEGUT will lead to improved treatments for Crohn’s disease and pave the way for a capsule-based platform adaptable to other diseases requiring targeted delivery in the gastrointestinal tract.”
Key Insights and Learnings
“So far, we have gained valuable insights into the variability of physiological parameters in Crohn’s disease patients and how these differences can impact drug product performance. Understanding these variations is crucial for optimising our capsule-based delivery system to ensure consistent and effective treatment.”
Publications
A review manuscript on the capsule-based innovations in targeted oral drug delivery and manufacturing technologies is in preparation.
What Sets GENEGUT Apart
“GENEGUT stands out for its diverse and impactful collaborations, uniting experts from various scientific fields and patient organisations. The commitment of all partners to excellence and cross-disciplinary learning is remarkable.“
Three Words That Describe GENEGUT
“Collaborative, innovative, insightful“