PhD positions in GENEGUT

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The GENEGUT consortium is currently recruiting highly motivated PhD candidates.
Find the open positions below: 

1 PhD Position in “Site Specific Delivery of RNA Therapies in the Lower Gastrointestinal Tract”

The School of Pharmacy at the University College Cork, Ireland is currently recruiting a fully funded PhD studentship under the GENEGUT Research and Innovation Action.

The PhD project at UCC will focus on the challenge of oral delivery of gene therapy to the terminal ileum, which aims to maximise the bio-accessibility and minimise systemic side-effects of RNA therapy. Furthermore, this project will provide proof of concept for localised, site specific delivery of NPs in a suitable preclinical pig model, which is widely regarded as comparable to human physiology. The pig is considered to be the most suitable non-primate animal model since it resembles the human better than any other non-primate. The successful candidate will also be involved in establishment and validation of an in vivo pig model of intestinal inflammation seen in Crohn’s Disease.

About the candidate

The successful candidate will be exceptionally enthusiastic, creative, and driven with a passion for interdisciplinary science and translational research and have a desire to apply their talents to high-impact work aimed at improving patient outcomes.

Eligibility criteria

  • Applicants must have a first class or upper second-class honours degree in pharmacy, pharmaceutical sciences or related disciplines e.g. Pharmaceutical Chemistry, Pharmacology.
  • M.Sc. degree is desirable but not essential.
  • Prospective Ph.D. students should have prior practical laboratory experience.
  • Prior experience with in vivo animal models is desirable but not essential.
  • Applicants must all meet UCC eligibility requirements for registration as a PhD student.

     

To apply and for further information click the link below:

2 PhD Positions in “Oral delivery of RNA therapeutics using novel biomaterials”

The School of Pharmacy at the University College Cork, Ireland is currently recruiting two wo highly motivated candidates who will join the the O’Driscoll Pharmacodelivery group and Kowalski lab for smart drug delivery technologies. The two PhD positions are fully funded under the GENEGUT Research and Innovation Action.

These PhD projects will focus on the design of nano formulations containing a range of RNA cargos including short interfering RNA (siRNA) and messenger RNA (mRNA). The formulations will be engineered using novel biomaterials based mainly on functionalised cyclodextrins (O’Driscoll lab) and novel polymers (Kowalski lab).

About the candidate

The successful candidate will be exceptionally enthusiastic, creative, and driven with a passion for interdisciplinary science and translational research and have a desire to apply their talents to high-impact work aimed at improving patient outcomes.

Eligibility criteria

  • Applicants must have a first class or upper second-class honours degree in Pharmacy, Pharmaceutical Sciences, Biomedical Engineering or related disciplines e.g. Pharmaceutical Chemistry, Pharmacology.
  • M.Sc. degree is desirable but not essential.
  • Prospective Ph.D. students should have prior practical laboratory experience.
  • Candidates should have strong interpersonal skills and excellent oral/written communication skills.
  • Experience in one or more of the following areas will be beneficial but is not required: RNA and drug delivery, anatomy and physiology of the gastrointestinal tract, formulation and preparation of nanoparticles, cyclodextrin/ polymer chemistry, intestinal cell culture models and animal work
  • Applicants must all meet UCC eligibility requirements for registration as a PhD student.

To apply and for further information click the link below:

2 PhD Positions in “Delivery of RNA Therapies to Cells and preclinical models”

APC Microbiome Ireland, School of Medicine and School of Biochemistry and Cell Biology, University College Cork, Ireland are currently recruiting two wo highly motivated candidates who will join the laboratories of Prof Subrata Ghosh, Dr Silvia Melgar and Dr Ken Nally, under the GENEGUT Research and Innovation Action. The two PhD positions are fully funded.

The UCC School of Pharmacy will develop novel biomaterials such as amphiphilic cyclodextrins and amino polyesters, to identify nanoparticles (NPs) suitable for intracellular delivery of RNA to cells in the small intestine. Once these RNA NPs formulations have been generated, the PhD candidates will evaluate their efficacy in targeting inflammatory pathways associated with Crohn’s disease pathogenesis in three relevant human intestinal cell types including immune (macrophages) and non-immune cells (fibroblasts and epithelial cells). The candidates will also investigate the mechanism of action of the delivered RNAs by using RNASeq and proteomics analysis, the latter in collaboration with partners at Uppsala University, Sweden. Finally, a disease relevant large animal model will be established and validated in collaboration with the School of Pharmacy, UCC. This will be used to assess the efficacy of the orally delivered encapsulated RNAs to the small intestine of the pigs with a focus on inflammation and identified responses in the cell-systems.

About the candidate

The two PhD candidates will conduct a specific programme of research under the supervision of Dr Silvia Melgar and Dr Ken Nally.

The successful candidates will be able to develop and apply cell and molecular biology skills, work in a cross-disciplinary research team and work closely with our academic and industry collaborators, including RNA biologists, pharmacologists, nanomedicine experts, drug delivery experts, and clinical scientists. The candidates should have strong interpersonal skills and excellent oral/written communication skills.

Eligibility criteria

  • Applicants must have a first class or upper second-class honours degree in Biochemistry, Biotechnology, Cell biology, Immunology, Molecular Biology, or a life science area
  • M.Sc. degree is desirable but not essential
  • Prospective Ph.D. students should have prior practical laboratory experience
  • Prior experience with in vivo animal models and bioinformatics is desirable but not essential
  • Applicants must all meet UCC eligibility requirements for registration as a PhD student

To apply and for further information click the link below: